美 연구팀, "개똥쑥 항암효과 1200배" 발표.
미국 워싱턴대학 연구팀은 암을 죽이는 능력이 기존 약보다 1200배
가까이 되는 약초에 대해 보고했다.
연구팀은 '암 저널(Cancer Letters)'을 통해 '개똥쑥(Artemisia annua L)'에
대해 "암 세포만을 선택적 으로 공격하도록 처리한 후 백혈병 세포에
투여했더니 폭탄처럼 암 세포를 죽이는 것으로 조사됐다"며
"전립선암과 유방암 치료에도
쓰일 수 있는지 연구를 진행 중"이라고 밝혔다.
개똥쑥은 국화과 식물로 한국, 일본, 대만, 몽골, 시베리아 등에서
자란다. 길가나 빈터, 강가에서 볼 수 있으며 풀 전체에 털이 없고
특이한 냄새가 난다.
개똥쑥의 플라보노이드 성분은 항말라리아 효과를 말라리아
치료제 아테미신 제조에도 쓰이고 있다
국화과의 일년초인 개똥쑥은 빈터나 길가, 강가 등에서 볼 수 있는데,
줄기에 털이 없으며 녹색이고 높이는 1m 정도이다.
꽃은 작은 두상화서가 수상으로 달려서 전체가 원추화서로 되어
6-8월에 피고 두화는 황색이고 대개 구형이다.
열매는 수과로써 담갈색으로 9월에 익는다.
개똥쑥은 전초를 청호(靑蒿), 黃花蒿(황화호)라 하고, 과실은
황화호자(黃花蒿子)라
하여 가을에 채취, 햇볕에 말려서 말라리아에 의한 뇌성마비,
소아경련, 청열, 조열, 양혈, 도한, 해열제로 결핵의 열, 만성 간혈열,
산욕열, 신경성 열병, 황달에
달여서 복용하거나 악창, 개선(옴), 지혈, 변혈, 벌독에 외용제로
짓찧어서 사용한다. 또한 황화호자(黃花蒿子)인 열매를 달여서
복용하면 피로, 하기(下氣), 개위(開胃)에 좋다.
개똥쑥에 대한 미국의 원문 내용은 아래과 같다.
[Scientists develop new cancer-killing compound from salad plant
Oct. 13, 2008/Science/Health and Medicine
Researchers at the University of Washington have updated a traditional Chinese medicine to create a compound that is more than 1,200 times more specific in killing certain kinds of cancer cells than currently available drugs, heralding the possibility of a more effective chemotherapy drug with minimal side effects.
The new compound puts a novel twist on the common anti-malarial drug artemisinin, which is derived from the sweet wormwood plant (Artemisia annua L). Sweet wormwood has been used in herbal Chinese medicine for at least 2,000 years, and is eaten in salads in some Asian countries.
The scientists attached a chemical homing device to artemisinin that targets the drug selectively to cancer cells, sparing healthy cells. The results were published online Oct. 5 in the journal Cancer Letters.
"The compound is like a special agent planting a bomb inside the cell," said Tomikazu Sasaki, chemistry professor at UW and senior author of the study.
In the study, the UW researchers tested their artemisinin-based compound on human leukemia cells. It was highly selective at killing the cancer cells. The researchers also have preliminary results showing that the compound is similarly selective and effective for human breast and prostate cancer cells, and that it effectively and safely kills breast cancer in rats, Sasaki said.
Cancer drug designers are faced with the unique challenge that cancer cells develop from our own normal cells, meaning that most ways to poison cancer cells also kill healthy cells. Most available chemotherapies are very toxic, destroying one normal cell for every five to 10 cancer cells killed, Sasaki said. This is why chemotherapy's side effects are so devastating, he said.
"Side effects are a major limitation to current chemotherapies," Sasaki said. "Some patients even die from them."
The compound Sasaki and his colleagues developed kills 12,000 cancer cells for every healthy cell, meaning it could be turned into a drug with minimal side effects. A cancer drug with low side effects would be more effective than currently available drugs, since it could be safely taken in higher amounts.
The artemisinin compound takes advantage of cancer cell's high iron levels. Artemisinin is highly toxic in the presence of iron, but harmless otherwise. Cancer cells need a lot of iron to maintain the rapid division necessary for tumor growth.
Since too much free-floating iron is toxic, when cells need iron they construct a special protein signal on their surfaces. The body's machinery then delivers iron, shielded with a protein package, to these signals proteins. The cell then swallows this bundle of iron and proteins.
Artemisinin alone is fairly effective at killing cancer cells. It kills approximately 100 cancer cells for every healthy cell, about ten times better than current chemotherapies. To improve those odds, the researchers added a small chemical tag to artemisinin that sticks to the "iron needed here" protein signal. The cancer cell, unaware of the toxic compound lurking on its surface, waits for the protein machinery to deliver iron molecules and engulfs everything -- iron, proteins and toxic compound.
Once inside the cell, the iron reacts with artemisinin to release poisonous molecules called free radicals. When enough of these free radicals accumulate, the cell dies.
"The compound is like a little bomb-carrying monkey riding on the back of a Trojan horse," said Henry Lai, UW bioengineering professor and co-author of the study.
The compound is so selective for cancer cells partly due to their rapid multiplication, which requires high amounts of iron, and partly because cancer cells are not as good as healthy cells at cleaning up free-floating iron.
"Cancer cells get sloppy at maintaining free iron, so they are more sensitive to artemisinin," Sasaki said.
Cancer cells are already under significant stress from their high iron contents and other imbalances, Sasaki said. Artemisinin tips them over the edge. The compound's modus operandi also means it should be general for almost any cancer, the researchers said.
"Most currently available drugs are targeted to specific cancers," Lai said. "This compound works on a general property of cancer cells, their high iron content."
The compound is currently being licensed by the University of Washington to Artemisia Biomedical Inc., a company Lai, Sasaki and Narendra Singh, UW associate professor of bioengineering, founded in Newcastle, Wash. for development and commercialization. Human trials are at least several years away. Artemisinin is readily available, Sasaki said, and he hopes their compound can eventually be cheaply manufactured to help cancer patients in developing countries.
Other authors of the study are Steve Oh, UW medical student; Byung Ju Kim, UW chemistry instructor; and Singh.
The Washington Technology Center and the Witmer Foundation provided funding for the study. ]
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암환자가 복용하기 좋게 환으로 제조 공급 합니다
비해 1200배라고 발표했다 *방송내용 아래에 녹화되있음.
페암.간암.위암.유선암.황달.신장.방광,결석등 각종암 에... 복용방법~아침 저녁 식후 35알 ~ 45알씩 물로 먹는다
살아있는 개똥쑥 개똥쑥 생재모습 개똥쑥 환 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ▶ 항암작용, 담즙분비작용, 면역조절작용, 학질 원충 억제 작용, 혈압 강하 작용, 피부 진균 억제 작용, 쓴맛건위약, 열내림약, 피멎이약, 고혈압, 만성기관지염, 진해, 거담, 천식, 홍반성낭창, 간디스토마, 구강 점막의 편평태선, 결핵열, 학질(말라리아), 변비해소, 여름철 더위로 인한 메스꺼움, 구토, 가슴이 답답하고 열이 많은 증상, 뼛골이 쑤시면서 열이 날 때, 손과 발에 열이 나는 증상, 여름 감기에 열이 나면서 아픈데, 간헐열, 황달, 신경성 열병, 만성 열병, 혈변, 토혈, 염증약, 곪은 상처를 빨리 터지게 하는 약, 각종암, 폐암, 간암, 위암, 유선암, 백혈병, 피부병, 벌에 쏘인 데, 태선, 옴, 농피증, 류마티즘, 황달에 효험 |
